Yes, depending on the PC operating system and EEPROM settings.
For Windows XP and Windows 2000, the CDM drivers can be used. These will allow VCP drivers for one port and D2XX for the other.
For Windows 98 and Windows ME, the FTC drivers need to be used to install a device as VCP and the FTCD2XX drivers need to be used to install a device as D2XX. These drivers cannot be installed at the same time, so both ports must be configured to be VCP or D2XX, not a combination of the two.
In addition, the EEPROM driver settings dictate which drivers are loaded. These can be changed using the MProg utility from our Utilities web page.